Blar i NTNU Open på forfatter "Burchell, Joy"
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Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers
Hadjialirezaei, Soosan; Picco, Gianfranco; Beatson, Richard; Burchell, Joy; Stokke, Bjørn Torger; Sletmoen, Marit (Journal article; Peer reviewed, 2017)Carbohydrate–protein interactions govern many crucial processes in biological systems including cell recognition events. We have used the sensitive force probe optical tweezers to quantify the interactions occurring between ... -
The breast cancer-associated glycoforms of MUC1, MUC1-Tn and sialyl-Tn, are expressed in COSMC wild-type cells and bind the C-type lectin MGL
Beatson, Richard; Maurstad, Gjertrud; Picco, Gianfranco; Arulappu, Appitha; Coleman, Julia; Wandell, Hans H; Clausen, Henrik; Mandel, Ulla; Taylor-Papadimitriou, Joyce; Sletmoen, Marit; Burchell, Joy (Journal article, 2015)Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific ... -
Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions
Sletmoen, Marit; Gerken, Thomas A.; Stokke, Bjørn Torger; Burchell, Joy; Brewer, C. Fred (Journal article; Peer reviewed, 2018)The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. ...